[1]孙利华,保肇实,张传宝,等.趋化因子受体4在人脑胶质瘤中的表达及临床意义[J].临床神经外科杂志,2016,(03):189-192.
 SUN Li hua,BAO Zhao-shi,ZHANG Chuan-bao,et al.Prognostic and clinicopathological features of glioma with CXCR4 expression[J].Journal of Clinical Neurosurgery,2016,(03):189-192.
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趋化因子受体4在人脑胶质瘤中的表达及临床意义()
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《临床神经外科杂志》[ISSN:1672-7770/CN:32-1727/R]

卷:
期数:
2016年03期
页码:
189-192
栏目:
论著
出版日期:
2016-06-10

文章信息/Info

Title:
Prognostic and clinicopathological features of glioma with CXCR4 expression
作者:
孙利华保肇实张传宝羊正祥
214023无锡,南京医科大学附属无锡市人民医院神经外科(孙利华,羊正祥);首都医科大学附属北京天坛医院神经外科(保肇实);北京市神经外科研究所(张传宝)
Author(s):
SUN LihuaBAO Zhao-shiZHANG Chuan-baoet al.
Department of Neurosurgery,the Affiliated Wuxi People’s Hospital of Nanjing Medical University,Wuxi 214023,China
关键词:
胶质瘤CXCR4预后治疗靶点
Keywords:
gliomaCXCR4prognosistarget
文献标志码:
A
摘要:
目的:探索趋化因子受体4(CXCR4)在人脑胶质瘤中的表达,与临床特征间的关系及其在预后判断中的作用。方法:对中国脑胶质瘤基因组图谱计划(CGGA)中305例mRNA芯片数据中进行CXCR4表达分析;在REMBRANDT mRNA芯片数据库、GSE16011 mRNA芯片数据库及TCGA RNA测序数据库中验证CXCR4在胶质瘤中的表达特征。KaplanMeier生存曲线及Cox分析评价CXCR4在胶质瘤患者预后判断中的作用,Gene ontology(GO)分析CXCR4正相关表达基因功能。结果:CXCR4表达量随胶质瘤级别增高而升高,CXCR4高表达患者的预后生存期短。CXCR4生物学功能可能与机体免疫、炎症、创伤应答,细胞激活及黏附有关。结论:CXCR4可作为胶质瘤患者预后判断的指标及潜在的治疗靶点。
Abstract:
Abstract:Objective:To investigate the expression pattern and prognostic value of chemokine receptor 4(CXCR4) in gloma,relationship with clinicopathological features.Methods:Whole genome mRNA expression microarray data of 305 WHO ⅡⅣ glioma samples from Chinese Glioma Genome Atlas (CGGA) database was obtained as the discovery set.KaplanMeier survival analysis was used to estimate the survival distributions.Moreover,Gene ontology was performed for functional annotation of CXCR4.REMBRANDT,GSE16011 mRNA datasets and TCGA RNA sequence dataset were obtained as validation sets.Results:CXCR4 overexpression was significantly associated with high grade glioma.Furthermore,high CXCR4 expression conferred a worse survival.Additionally,GO analysis showed that CXCR4 was associated with immune and inflammatory response,cell activation and adhesion.Conclusion:CXCR4 might serve as a novel prognostic biomarker with potential therapeutic implications in glioma.

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备注/Memo

备注/Memo:
国家自然科学青年基金(81302183),江苏省自然科学基金(BK20141099)
更新日期/Last Update: 2016-06-15