[1]王之涵,沙龙贵,任力,等.脑挫伤患者血清和脑脊液神经元特异性烯醇化酶及髓鞘碱性蛋白水平的改变[J].临床神经外科杂志,2018,15(05):380-383.[doi:10.3969/j.issn.1672-7770.2018.05.015]
 WANG Zhi-han,SHA Long-gui,REN Li,et al.Changes and clinical significance of NSE and MBP levels in serum and cerebrospinal fluid in patients with cerebral contusion[J].Journal of Clinical Neurosurgery,2018,15(05):380-383.[doi:10.3969/j.issn.1672-7770.2018.05.015]
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脑挫伤患者血清和脑脊液神经元特异性烯醇化酶及髓鞘碱性蛋白水平的改变()
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《临床神经外科杂志》[ISSN:1672-7770/CN:32-1727/R]

卷:
15
期数:
2018年05期
页码:
380-383
栏目:
临床研究
出版日期:
2018-10-15

文章信息/Info

Title:
Changes and clinical significance of NSE and MBP levels in serum and cerebrospinal fluid in patients with cerebral contusion
作者:
王之涵沙龙贵任力徐豪周新军
201300上海,复旦大学附属上海市浦东医院神经外科
Author(s):
WANG Zhi-hanSHA Long-guiREN Liet al.
Department of Neurosurgery,Shanghai Pudong Hosptial,Fudan University Pudong Medical Center,Shanghai 201300,China
关键词:
颅脑损伤神经元特异性烯醇化酶髓鞘碱性蛋白
Keywords:
cerebral contusionneuron-specific enolasemyelin basic protein
分类号:
R641
DOI:
10.3969/j.issn.1672-7770.2018.05.015
文献标志码:
D
摘要:
目的 探讨脑挫伤患者血清和脑脊液神经元特异性烯醇化酶(NSE)和髓鞘碱性蛋白(MBP)水平的变化及临床意义。方法 选取2013年1月至2016年9月间复旦大学附属上海市浦东医院收治的115例颅脑损伤(TBI)后脑挫伤患者,根据入院时格拉斯哥昏迷量表(GCS)评分,分为轻型、中型、重型和特重型组。并以同时期30位门诊健康检查者为正常对照组。分别在患者入院后第1、2、3、7、10 d,正常对照者健康检查时,检测其血清及脑脊液NSE、MBP浓度。对中、重型脑损伤患者的血清NSE和MBP水平与其颅内压(ICP)进行ROC分析。结果 脑挫伤各组的血清和脑脊液NSE、MBP水平均明显高于正常对照组(均P<0.05);而脑挫伤重型、特重型组又明显高于轻型和中型组(均P<0.05)。ROC分析显示,血清和脑脊液NSE和MBP水平对中、重型颅脑损伤患者的手术指征有参考价值。结论 血清和脑脊液NSE、MBP水平与脑挫伤严重程度有显著关系。结合GCS评分和ICP,NSE和MBP可对脑挫伤程度、病情发展评估提供参考,特别为中、重型患者的手术指征提供依据。
Abstract:
Abstract:Objective To investigate the changes and clinical significance of neuron-specific enolase(NSE) and myelin basic protein(MBP) in serum and cerebrospinal fluid of patients with cerebral contusion.Methods From January 2013 to September 2016,115 cases of traumatic brain injury(TBI) with cerebral contusion were selected as trauma group.According to the GCS score at admission,the patients were divided into mild group,moderate group,severe group and especially severe group.The levels of NSE and MBP in serum and cerebrospinal fluid were measured at 1,2,3,7 and 10 days after admission.The serum and cerebrospinal fluid samples of 30 outpatients were used as control group.ROC analysis was used in serum NSE and MBP concentrations in patients with moderate-severe brain injury and intracranial pressure (ICP).Results The levels of NSE and MBP in the serum and cerebrospinal fluid of each group were significantly higher than those in the control group (all P<0.05).The levels of NSE and MBP in serum and cerebrospinal fluid were significantly different between the two groups (all P<0.05).Serum and cerebrospinal fluid NSE and MBP concentration was valuable to moderate to severe craniocerebral injury in patients with surgical indications.Conclusions NSE and MBP are proportional to the severity of injury.GCS and ICP,NSE and MBP can provide reference for the severity of cerebral contusion,the progression and prognosis of the patients and the surgical indication of moderate to severe patients.

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更新日期/Last Update: 2018-10-10