[1]刘永亮,李建民,赵雅宁,等.磁共振成像评估丁苯酞软胶囊对创伤性脑水肿大鼠的治疗作用[J].临床神经外科杂志,2014,(01):21-24.
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磁共振成像评估丁苯酞软胶囊对创伤性脑水肿大鼠的治疗作用
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《临床神经外科杂志》[ISSN:1672-7770/CN:32-1727/R]

卷:
期数:
2014年01期
页码:
21-24
栏目:
论著
出版日期:
2014-02-28

文章信息/Info

作者:
刘永亮 李建民 赵雅宁 王鹏
河北联合大学附属唐山市人民医院
关键词:
创伤性脑损伤脑水肿磁共振成像丁苯酞
摘要:
目的:运用磁共振成像探索大鼠创伤性脑水肿的演变规律及丁苯酞软胶囊对其的治疗作用。方法:SD雄性大鼠175只。随机分为非干预组、干预组和正常对照组。采用Marmarou法制作创伤性脑水肿大鼠模型,造模成功后分别于6h、12h、1天、3天、7天行磁共振成像扫描、HE染色、脑组织含水量测定、伊文思蓝渗出量测定。结果:磁共振成像、HE染色、和脑组织含水量测定结果提示与对照组相比,非干预组和干预组脑组织可见明显脑水肿,其中以损伤后24小时最明显,3天后开始减轻。干预组较非干预组脑水肿程度明显减轻。伊文思蓝渗出检测提示,创伤性脑损伤后伊文思蓝渗出量增多,其中以6h渗出量最多。非干预组较干预组渗出明显。结论:创伤性脑损伤后,继发血管源性脑水肿和细胞毒性脑水肿,其中以1天时脑水肿最明显,丁苯酞软胶囊能明显减轻脑损伤后脑水肿的形成。

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备注/Memo

备注/Memo:
[收稿日期] 2013-11-15
更新日期/Last Update: 2014-02-15