[1]刘亮,王莹,朱正权,等.新疆维吾尔族胶质瘤中ATM及PTEN蛋白的表达与临床意义[J].临床神经外科杂志,2015,(01):9-12.
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新疆维吾尔族胶质瘤中ATM及PTEN蛋白的表达与临床意义()
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《临床神经外科杂志》[ISSN:1672-7770/CN:32-1727/R]

卷:
期数:
2015年01期
页码:
9-12
栏目:
胶质瘤专题
出版日期:
2015-02-15

文章信息/Info

Title:
The Expression and Clinical Significance of ATM and PTEN in Gliomas of Uygar in Xinjiang
作者:
刘亮 王莹 朱正权 夏海成 栾新平 屈建强 杜山别克
新疆医科大学附属肿瘤医院
关键词:
胶质瘤维吾尔族ATMPTEN生存期免疫组化
Keywords:
Gliomas Uygar ATM PTEN clinical significance survival time immunohistochemistry
分类号:
R651.1
文献标志码:
A
摘要:
目的:探讨新疆维吾尔族胶质瘤中ATM及PTEN蛋白的表达与临床意义。方法:运用免疫组化法检测50例胶质瘤中ATM及PTEN蛋白的表达情况,同时以20例胶质瘤旁组织作为对照,分析其表达差异及其表达与胶质瘤临床病理特征、患者生存期之间的关系。结果:(1)新疆维吾尔族胶质瘤和胶质瘤旁组织中ATM蛋白表达的阳性率分别为60%(30/50)和10%(2/20);PTEN蛋白表达的阳性率分别为30%(15/50)和75%(15/20);(2)ATM及PTEN蛋白表达在胶质瘤和胶质瘤旁组织中的表达差异有统计学意义(P<0.05);(3)ATM蛋白及PTEN蛋白均在WHO分级、不同生存期各组中的差异有统计学意义(P<0.05),在临床表现、性别、肿瘤大小、肿瘤部位、是否复发各组之间的差异均无统计学意义(P>0.05)。结论:(1)ATM及PTEN蛋白在新疆维族胶质瘤中及胶质瘤旁组织中表达有差异,表明ATM及PTEN蛋白在胶质瘤发生发展中可能起到一定作用;(2)新疆维族胶质瘤中ATM及PTEN蛋白均与WHO分级和不同生存期表达相关,提示ATM及PTEN蛋白可作为判定胶质瘤生物学行为和预后判断的参考指标。
Abstract:
Objective: To approach the expression and clinical significance of ATM and PTEN in Gliomas of Uygar in Xinjiang. Method: Immunohistochemistry was used to detect the expression of ATM and PTEN between 50 cases of Gliomas and 20 cases of adjacent tissues. Results: (1) The positive rate of ATM in Gliomas and adjacent tissues respectively were 60%(30/50)and 10%(2/20). The positive rate of PTEN in Gliomas and adjacent tissues respectively were 30%(15/50)and 75%(15/20)(2) The difference of the expression of ATM and PTEN between Gliomas and adjacent tissues was statistically significant (P<0.05). (3)The differences of the expression of ATM and PTEN in different WHO histological grading and survival time groups were statistically significant (P<0.05); The expression of ATM in different clinical performances, gender, tumor size, tumor position and recurrence or not groups had no statistical difference (P>0.05) . Conclusion: (1) The expression of ATM and PTEN in Gliomas of Uygar in Xinjiang was differ from which in adjacent tissues may show that ATM and PTEN may play a certain role in the development and progression of Gliomas of Uygar in Xinjiang. (2) The expression of ATM and PTEN of Uygar in Xinjiang was related to WHO histological grading and survival time. They can be the judgers of the biological behavior,prognosis factor of Gliomas of Uygar in Xinjiang.

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备注/Memo

备注/Memo:
[收稿日期] 2014-08-22 [基金项目] 新疆医科大学创新基金
更新日期/Last Update: 2015-02-15