[1]倪春霞,汪洋,盛晓芳.应用DWI和DTI勾画在高级别胶质瘤术后放疗靶区的初步研究[J].临床神经外科杂志,2015,(03):223-226.
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应用DWI和DTI勾画在高级别胶质瘤术后放疗靶区的初步研究()
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《临床神经外科杂志》[ISSN:1672-7770/CN:32-1727/R]

卷:
期数:
2015年03期
页码:
223-226
栏目:
论著
出版日期:
2015-06-15

文章信息/Info

Title:
Primary study of the value for DWI and DTI in the delineation of radiotherapy target volume for patients with post-operative high-grade glioma
作者:
倪春霞 汪洋 盛晓芳
复旦大学附属华山医院上海伽玛医院肿瘤放疗中心
关键词:
胶质瘤扩散加权成像弥散张量成像放射治疗
Keywords:
gliomadiffusion-weighted imaging diffusion-tensor imaging radiation
分类号:
R739.41
文献标志码:
A
摘要:
目的: 初步探讨MRI扩散加权成像(DWI)和弥散张量成像(DTI)在高级别胶质瘤(HGG)术后放疗靶区勾画中的应用价值 方法:对我院收治的HGG术后残留患者入组做前瞻性研究。所有患者放疗前行DWI和DTI检查,在ADC图和FA图上分别测量残留肿瘤、肿瘤外1cm区域内(定义为近瘤周区)、1-2cm区域内(定义为中瘤周区)、2-3cm区域内(定义为远瘤周区)及3-4cm区域内(定义为瘤周区外)和对侧正常脑组织的ADC平均值、ADC最小值、FA平均值和FA最小值。结果:2013年9月至2014年8月,共有55例HGG患者入组,ADC平均值和最小值呈现从残留肿瘤、近瘤周区到中瘤周区逐渐升高的趋势,并从中瘤周区、远瘤周区到瘤周区外逐渐降低;其中,残留肿瘤与近瘤周区,中瘤周区与远瘤周区、以及远瘤周区与瘤周区外比较,差异均有统计学意义(P<0.05); FA平均值和最小值呈现从残留肿瘤、近瘤周区、中瘤周区、远瘤周区到瘤周区外逐渐升高的趋势,但各区差别无统计学意义(P>0.05)。结论: 本研究初步显示DWI技术可能有助于术后HGG及肿瘤周边组织性质的确定,指导HGG术后放疗靶区的勾画;FA值对于靶区勾画的价值有待进一步研究。
Abstract:
Objective To explore the values of DWI and DTI in the delineation of radiotherapy target volume for patients with post-operative high-grade glioma. Methods The postoperative HGG patient with residual tumor was included in this prospective study. All patients were performed DWI and DTI MRI pre-radiotherapy. The average and minimum values of ADC and FA were measured in residual tumor, peritumoral tissue and the corresponding normal tissue. The peritumoral tissue is divided into four areas: 1cm distance from tumor margin (defined as the proximal area); 1-2 cm distance from tumor margin (defined as the middle area);2-3 cm distance from tumor margin (defined as the distal area) ; 3-4 cm distance from tumor margin (defined as the outside area) Results From Sep.2013 to Aug.2014, 55 patients were included. The average and minimum ADC values are increased from the residual tumor to the middle area, which are statistically significant; and then the values become decreased from middle area to outside area, although the difference was not significant. The average and minimum FA values are gradually increased, but no significant difference was found. Couclusion DWI could help define the nature of residual tumor and peritumoral tissue, which could present valuable information for target delineation for high-grade glioma after operation. The value of FA need further study.

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备注/Memo

备注/Memo:
[收稿日期] 2015-03-27 基金项目:上海市卫计委科研课题
更新日期/Last Update: 2015-06-15