[1]王勇,吴冲,张洪亮,等.神经内镜下切除功能性垂体瘤术后激素水平改善的效果分析[J].临床神经外科杂志,2015,(04):265-273.
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神经内镜下切除功能性垂体瘤术后激素水平改善的效果分析()
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《临床神经外科杂志》[ISSN:1672-7770/CN:32-1727/R]

卷:
期数:
2015年04期
页码:
265-273
栏目:
论著
出版日期:
2015-08-15

文章信息/Info

Title:
Transsphenoidal endoscopic surgery in the treatment of functional pituitary adenoma: comparison of therapeutic benefits of hormone levels.
作者:
王勇 吴冲 张洪亮 王义宝
中国医科大学附属第一医院神经外科
关键词:
功能性垂体瘤显微镜神经内镜激素改善
Keywords:
functional pituitary adenoma microsurgery endoscopic surgery clinical benefits of hormone
分类号:
R651.1
文献标志码:
A
摘要:
目的 探讨神经内镜与显微镜经鼻切除功能性垂体瘤术后激素改善的差异性。方法 收集并分析中国医科大学附属第一医院神经外科2009年3月~2013年11月笔者所在治疗组58例功能性垂体瘤患者临床资料。将58例患者按手术方式不同分为两组,显微镜下单鼻孔经鼻蝶手术组34例;神经内镜下经鼻蝶手术组24例。每组患者根据不同激素功能类型分为:泌乳素腺瘤(PRL)、生长激素腺瘤(GH)、促肾上腺皮质激素腺瘤(ACTH)。所有患者术后随访皆行垂体激素化验及影像学检查。结果:显微镜组34例,术后激素恢复正常15例(44.1%),下降>术前激素水平50% 13例(38.2%),无变化6例(17.4%);内镜组共24例,术后恢复正常17例(70.8%), 下降>术前激素水平50% 2例(8.3%),无变化5例(21%)。结论 :神经内镜经蝶手术切除功能性垂体腺瘤能显著改善垂体激素水平,在一定程度上优于显微镜。
Abstract:
Objective To assess the difference of therapeutic benefits of hormone levels in transsphenoidal endoscopic surgery and microsurgery in the treatment of functional pituitary adenoma. Method The clinical data of 58 patients suffered from functional pituitary adenoma were collected and analyzed between March 2009 and November 2013. 58 subjects were divided into two groups according to different surgical approaches: microsurgery treatment group, which including 33 subjects performed the single-nostril transsphenoidal microsurgery approach; neuroendoscope treatment group, including 25 subjects, performed the neuroendoscope approach. The hormone-secreting types included prolactin (PRL),growth hormone( GH),andadrenocorticotropichormone( ACTH). Results microsurgery treatment group: the clinical symptoms improved in 15 subjects, falls by more than 50%in 13 subjects, 6 subjects had no obvious change. Neuroendoscope treatment group: the clinical symptoms improved in 17 subjects, falls by more than 50%in 2 subjects, 5 subjects had no obvious change. The rate of subjects whose hormone level fall to normal is higher in neuroendoscope treatment group than that in microsurgery treatment group.Conclusion: The endoscopic surgery had advantages in harmonic levels improvement compared to microsurgery surgery.

相似文献/References:

[1]王新栋,汤阳阳,刘厚强,等.神经内镜与显微镜下经鼻蝶垂体腺瘤切除的疗效比较[J].临床神经外科杂志,2018,15(04):292.
 WANG Xin-dong,TANG Yang-yang,LIU Hou-qiang,et al.Comparison of neuroendoscopic and transnasal-sphenoidal microscopic resection of pituitary adenoma[J].Journal of Clinical Neurosurgery,2018,15(04):292.

备注/Memo

备注/Memo:
[收稿日期] 2014-11-24 [基金项目]辽宁省自然科学基金
更新日期/Last Update: 2015-08-15