[1]赵东升,姬西团,费舟,等.颅脑外伤对青少年与儿童生长激素的影响[J].临床神经外科杂志,2015,(06):423-429.
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颅脑外伤对青少年与儿童生长激素的影响
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《临床神经外科杂志》[ISSN:1672-7770/CN:32-1727/R]

卷:
期数:
2015年06期
页码:
423-429
栏目:
颅脑损伤专题
出版日期:
2015-12-15

文章信息/Info

Title:
Effect on the changes of serum growth hormone in children and teenagers suffer from traumatic brain injury
作者:
赵东升 姬西团 费舟 孙刚锋
第四军医大学西京医院
关键词:
颅脑外伤青少年儿童生长激素
Keywords:
traumatic brain injury teenagers children growth hormone
分类号:
R651.1
文献标志码:
A
摘要:
目的:探讨颅脑外伤对青少年与儿童生长激素水平的影响。方法:将颅脑外伤后80例青少年患者分为儿童组(3~6岁)27例、少年组(7~12岁)32例、青春期(13~18岁)21例三个年龄组,分别在受伤后第1天、第7天凌晨空腹检测血清生长激素、IGF-1水平,与正常同龄人进行比较。结果:儿童组、少年组受伤后生长激素水平高于正常同龄儿(P<0.05),青春期组受伤后生长激素水平低于正常同龄儿(P<0.05)。儿童组及少年组伤后生长激素第1天升高,第7天下降。青春期组伤后生长激素降低,第7天逐渐升高。IGF-1受伤后均较同龄儿降低,随后逐渐升高。 结论:颅脑外伤后对青少年儿童患者生长激素及IGF-1水平产生明显影响,青春期患者影响更明显,尽早发现生长激素不足,并尽早干预可能改善长期预后。
Abstract:
Objective To detect the changes of growth hormone in children and teenagers suffered from traumatic brain injury. Methods We measured serum growth hormone(GH) levels in the 80 patients. Of the patients, there are children group(aged 3-6 years, n=27), juvenile group(aged 7-12 years, n=32),teenagers group(aged 13-18 years, n=21).The level of GH and IGF-1 were tested at 1st and 7th day after the brain injury, the results compared with the normal peers. Result The GH level of children and juvenile group are higher than the normal peers, the teenagers group are less than the normal peers. The GH level of children and juvenile group are rise in the 1st day, and decline in the 7th day, and the teenagers group decline after traumatic brain injury at once, then rise in the 7th day. The level of IGF-1are less than the normal peers after traumatic brain injury,and rise gradually. Conclusion The traumatic brain injury have evident effect on children and teenagers in growth hormone, the teenagers patients have a more apparent effect. Found that GH deficiency and supply it timely as soon as possible may improve the outcome

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备注/Memo

备注/Memo:
[收稿日期] 2015-06-09 [基金项目]国家自然科学基金
更新日期/Last Update: 2015-12-15