[1]张红波,陈谦学,穆林森.斜坡异位泌乳素垂体腺瘤1例临床分析并文献复习[J].临床神经外科杂志,2016,(01):16-20.
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斜坡异位泌乳素垂体腺瘤1例临床分析并文献复习()
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《临床神经外科杂志》[ISSN:1672-7770/CN:32-1727/R]

卷:
期数:
2016年01期
页码:
16-20
栏目:
颅底肿瘤专题
出版日期:
2016-03-01

文章信息/Info

Title:
Ectopic prolactinoma in clivus:one case report and review of the literature
作者:
张红波陈谦学穆林森
湖北省中西医结合医院(湖北省脑科中心)
关键词:
斜坡泌乳素垂体腺瘤异位神经内镜
Keywords:
ClivusProlactinPituitary adenomaEctopicNeuroendoscopy
文献标志码:
A
摘要:
目的 报告1例斜坡异位泌乳素垂体腺瘤(prolactinoma)病例并文献回顾。方法 通过临床症状、神经系统检查、内分泌学、影像学及病理结果确诊斜坡异位垂体腺瘤,并结合文献总结其临床特点。结果 1例51岁女性表现为头痛,高泌乳素血症,核磁共振发现斜坡病变,神经查体阴性。既往身体健康,术前诊断为脊索瘤。采用单鼻孔经鼻蝶入路,显微手术全切除肿瘤。肿瘤病理免疫组化泌乳素(prolactin,PRL)阳性,术后未完全降至正常,口服溴隐亭治疗,随访1年无复发。结论 斜坡异位垂体腺瘤临床罕见,误诊率高。以手术为主的综合治疗可获得理想的疗效。
Abstract:
Objective Report 1 case of ectopic prolactinoma in clivus and literature review.Methods By combination of the clinical symptom, neurologic examination, endocrinology, neuroimaging and pathological results this case were firmly diagnosed prolactinoma in clivus, and summarize its clinical characteristics through studying literature.Results 1 case of 51 year old women characterized by headache, hyperprolactinemia, magnetic resonance imaging(MRI) found that clivus disease, nervous physical examination was negative. The patient always in good healthy, the preoperative diagnosis of chordoma. Using single transnasalsphenoidal approach to totally removed the tumor in microneurosurgery. Tumor pathological immunohistochemical prolactin (PRL) is positive, not entirely down to normal in postoperative, and oral bromocriptine to alleviate the PRL level,no recurrence during 1 year follow-up.Conclusions the ectopic prolactinoma in clivus was rare and has a higher misdiagnosis rate.predominantly surgical comprehensive treatment can obtain ideal curative effect.

备注/Memo

备注/Memo:
[收稿日期] 2015-03-15 [基金项目]广东省公益研究与能力建设专项基金
更新日期/Last Update: 2016-02-15