[1]殷尚炯,程月飞,杜秀玉,等.WHOⅢ级脑膜瘤的生存分析[J].临床神经外科杂志,2016,(04):255-258.
 YIN Shang-jiong,CHENG Yue-fei,DU Xiu-yu,et al.Surviv alanalysis of World Health Organization grade Ⅲ meningiomas[J].Journal of Clinical Neurosurgery,2016,(04):255-258.
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WHOⅢ级脑膜瘤的生存分析()
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《临床神经外科杂志》[ISSN:1672-7770/CN:32-1727/R]

卷:
期数:
2016年04期
页码:
255-258
栏目:
脑膜瘤专题
出版日期:
2016-07-26

文章信息/Info

Title:
Surviv alanalysis of World Health Organization grade Ⅲ meningiomas
作者:
殷尚炯程月飞杜秀玉曹藏柱
075000张家口市,解放军251医院神经外科
Author(s):
YIN Shang-jiong CHENG Yue-fei DU Xiu-yu et al.
Department of Neurosurgery, 251 Hospital of PLA, Zhangjiakou 075000, China
关键词:
恶性脑膜瘤生存分析手术切除放疗
Keywords:
malignant meningioma survival analysis surgical resection radiotherapy
文献标志码:
A
摘要:
目的:探讨WHOⅢ级脑膜瘤患者的预后影响因素。方法:收集14例(男性4例,女性10例)经手术及病理诊断的WHOⅢ级脑膜瘤患者的临床及随访资料。应用Kaplan-Meier法和Cox回归模型对其性别、年龄、肿瘤部位、KPS评分、肿瘤切除程度,手术后放疗等临床特征进行单因素和多因素生存分析。结果本组14例患者的平均存活时间为60个月,中位生存时间为77个月,3年生存率为59%,5年生存率为51%,8年生存率为38%。12例大体全切的患者中平均复发时间为60个月,中位复发时间为43个月,3年复发率为55%,5年复发率为37%。单因素分析发现:性别(P=0.009)和手术切除程度(P=0.03)对WHOⅢ级脑膜瘤患者的生存时间有影响。Cox多因素预后分析未发现对生存时间和复发时间有影响的因素。结论:手术全切是延长WHOⅢ级脑膜瘤患者生存期的重要因素。
Abstract:
Abstract:Objective:To explore the outcomes and prognostic factors in patients with World Health Organization(WHO) gradeⅢ meningiomas. Methods:The clinical and follow-up data of 14 patients (4 males and 10 females) with WHO grade III meningiomas diagnosed by surgery and pathology were analyzed retrospectively. Univariate and multivariate analysis were performed between gender, age, tumor location, Karnofsky Performance Status (KPS),extent of resection,adjuvant radiology and survival time using Kaplan-Meier survival analysis and Cox proportional hazards models.Results:Of 14 patients,4 were male ,10 were female. with a mean survival of 60 months, with a median survival of 77 months. 3-year,5-year and 8-year overall survival (OS) were 59%,51% and 38% respectively. Of 12 patients with surgical gross-total resection, there were a mean survival time of 60 months, with a median survival time of 43 months.3-year,5-year recurrence-free survival (RFS) were 55% and 37% respectively. Univariate analysis showed the gender(P=0.009) and surgical extent of resection(P=0.03) have statistically significant effect on OS. All factors were not found statistically significant effect on OS and RFS by Cox proportional hazards models. Conclusions:Surgical gross-total resection were key means to prolong survival time of patients with World Health Organization grade Ⅲ meningiomas.

相似文献/References:

[1]余鹏霄,马晓东,张猛,等.恶性脑膜瘤的临床特点及诊疗体会[J].临床神经外科杂志,2015,(03):220.
[2]曾剑平,刘青,林志雄.脑胶质瘤病人预后相关影响因素分析[J].临床神经外科杂志,2015,(06):410.

更新日期/Last Update: 2016-08-10