[1]林久銮,孙朝晖,张冰清,等.迷走神经刺激术治疗难治性癫痫(附25例报告)[J].临床神经外科杂志,2016,(06):415-418.
 LIN Jiu-luan,SUN Zhao-hui,ZHANG Bing-qing,et al.Vagus nerve stimulation for intractable epilepsy(report of 25 cases)[J].Journal of Clinical Neurosurgery,2016,(06):415-418.
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迷走神经刺激术治疗难治性癫痫(附25例报告)()
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《临床神经外科杂志》[ISSN:1672-7770/CN:32-1727/R]

卷:
期数:
2016年06期
页码:
415-418
栏目:
神经调控专题
出版日期:
2016-12-25

文章信息/Info

Title:
Vagus nerve stimulation for intractable epilepsy(report of 25 cases)
作者:
林久銮孙朝晖张冰清王海祥宋宪成刘一鸥丰倩徐成伟柏建军周文静
100040,北京,清华大学玉泉医院癫痫中心
Author(s):
LIN Jiu-luan SUN Zhao-hui ZHANG Bing-qing et al.
Epilepsy Center of Yuquan Hospital, Tsinghua University, BeiJing 100040, China
关键词:
难治性癫痫 迷走神经刺激术 治疗效果
Keywords:
intractable epilepsy vagus nerve stimulation curative effects
分类号:
R454.1,R322.81
文献标志码:
A
摘要:
目的:研究迷走神经刺激术治疗难治性癫痫的适应证选择、手术方法、术后程控及疗效。方法:2009年11月~2016年7月清华大学玉泉医院癫痫中心对25例难治性癫痫患者行迷走神经刺激术,术后给予程控管理控制癫痫发作;并通过随访回顾性分析术后疗效。结果:术后随访患者4个月~7年,其中癫痫发作频率减少达McHughⅠ级6例、Ⅱ级12例、Ⅲ级4例、Ⅳ级1例、Ⅴ级2例。手术前后癫痫发作频率对比,差异有统计学意义(P<0.05)。结论:迷走神经刺激术作为一种安全有效的辅助治疗难治性癫痫的方法,其治疗效果可以随着参数的调整和时间延长而增强,并可以一定程度改善患者的认知行为和生活质量。
Abstract:
Objective:To explore the curative effects of vagus nerve stimulation(VNS) on intractable epilepsy. Methods:The clinical data of 25 patients with intractable epilepsy, who were treated by VNS in our center from November 2009 to July 2016, were analyzed retrospectively. Results:The follow up from 4 months to7 years showed that of 25 patients, 6(24%) belonged in MCHugh grade Ⅰ, 12(48%) in grade Ⅱ, 4(16%) in grade Ⅲ and 3(12%) in grades Ⅳ~Ⅴ. Conclusions:VNS is a safe and effective method to treat the intractable epilepsy. VNS may make seizure frequency reduce over 50% in more than 60% patients with intractable epilepsy. The present results suggested that the curative effect is correlated with the stimulation parameter and duration.

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[2]王强,杨娟,罗杰,等.外伤后难治性癫痫的高危因素分析[J].临床神经外科杂志,2017,14(05):339.
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[3]李佳,林久銮,周文静,等.3D-Slicer软件在难治性癫痫外科手术计划可视化中的运用[J].临床神经外科杂志,2020,17(03):306.[doi:DOI:10.3969/j.issn.1672-7770.2020.03.014]
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备注/Memo

备注/Memo:
国家重点基础研究发展计划(973计划)(2012CB 720704);清华大学自主项目(2015THJ01)
更新日期/Last Update: 2016-12-15