[1]邓光策,李国峰,曾敏敏,等.经鼻-蝶显微切除垂体腺瘤的疗效及对不同内分泌激素水平的监测意义[J].临床神经外科杂志,2019,16(1):80-83.[doi:10.3969/j.issn.1672-7770.2019.01.019]
 DENG Guang-ce,LI Guo-feng,ZENG Min-min,et al.Surgical effect of pituitary adenoma by endonasal transsphenoidal approach and significance of monitoring different endocrine hormone levels[J].Journal of Clinical Neurosurgery,2019,16(1):80-83.[doi:10.3969/j.issn.1672-7770.2019.01.019]
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经鼻-蝶显微切除垂体腺瘤的疗效及对不同内分泌激素水平的监测意义 ()
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《临床神经外科杂志》[ISSN:1672-7770/CN:32-1727/R]

卷:
16
期数:
2019年第1期
页码:
80-83
栏目:
临床研究
出版日期:
2019-02-18

文章信息/Info

Title:
Surgical effect of pituitary adenoma by endonasal transsphenoidal approach and significance of monitoring different endocrine hormone levels
作者:
邓光策李国峰曾敏敏王岳华关北漩李凯舒
511500 清远,广州医科大学附属第六医院,清远市人民医院神经外科
Author(s):
DENG Guang-ce LI Guo-feng ZENG Min-min et al.
Department of Neurosurgery, the Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital, Qingyuan 511500, China
关键词:
单鼻孔蝶窦入路显微手术垂体腺瘤
Keywords:
unilateral endonasal transsphenoidal microsurgery pituitary adenoma
分类号:
R739.41;R651.1+3
DOI:
10.3969/j.issn.1672-7770.2019.01.019
文献标志码:
D
摘要:
目的探讨经单鼻孔蝶窦入路显微手术切除垂体腺瘤的临床疗效。方法回顾性分析广州医科大学附属第六医院神经外科2010年1月—2017年6月,行经单鼻蝶窦入路显微镜下手术切除垂体腺瘤的145例患者的临床资料。比较分析其手术切除范围、术后临床疗效及手术前后血清催乳素(prolactin,PRL)、生长激素(growth hormone,GH)水平。结果本组患者术后半年时,头痛、视野缺损、视力减退、神经内分泌紊乱(泌乳闭经、性功能障碍、肢端肥大、激素水平异常、向心性肥胖等)等症状明显改善。肿瘤全切组患者术后第1 d、第7 d、第14 d的血清PRL、GH激素水平较术前均明显下降,而未全切组患者无明显变化。手术全切组患者术后第1 d、第7 d、第14 d的血清PRL、GH激素水平比术前明显降低,差异有统计学意义(均P<0.005)。结论经单鼻孔蝶窦显微手术切除垂体腺瘤,具有创伤小、手术时间短及并发症低等优点;并能明显改善临床症状和血激素水平;具有较高的临床应用价值。
Abstract:
Abstract: ObjectivesTo explore the surgical effect of pituitary adenoma by unilateral endonasal transsphenoidal approach. MethodsThe clinical data of 145 patients with pituitary adenoma microsurgery resection by unilateral endonasal transsphenoidal approach in the Sixth Affiliated Hospital of Guangzhou Medical University between January 2010 and June 2017 were analyzed retrospectively. Resection rang,clinical effect and the level of serum prolactin(PRL) and growth hormone(GH) before and after surgery were compared. ResultsAll 145 cases were followed by 6 months, clinical symptoms, including headache、 visual field defects、 visual deterioration、 nero-endocrine disorders(amenorrhea lactation, sexual dysfunction, acral growth,abnormal hormone levels, centrality obesity, etc) were improved significantly. The level of serum PRL and GH were significantly lower than before operation on postoperative 1 d, 7 d, 14 d, but no obvious change in uncomplete tumor resection group. The level of serum PRL and GH on postoperative 1 d, 7 d, 14 d were obviously lower compared with two groups, the difference was statiscally significant(P<0.005). ConclusionPituitary Adenoma Resection by Unilateral Endonasal Transsphenoidal Approach has certain advantages of small trauma,little invasion, and low complicationsl et.besides can obviously improve clinical symptoms and the hormone levels of PRL or GH, therefore it is of high value in clinical application.

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更新日期/Last Update: 2019-02-18