[1]陈克非,代飞虎,李光旭,等.CT灌注成像评估兔创伤性脑损伤后不同干预方式下脑血流动力学的变化[J].临床神经外科杂志,2019,16(1):84-88.[doi:10.3969/j.issn.1672-7770.2019.01.020]
 CHEN Ke-fei,DAI Fei-hu,LI Guang-xu,et al.Preliminary study on assessment of cerebral hemodynamics changes (under different intervention methods)after traumatic brain injury in rabbits by computed tomography perfusion imaging[J].Journal of Clinical Neurosurgery,2019,16(1):84-88.[doi:10.3969/j.issn.1672-7770.2019.01.020]
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CT灌注成像评估兔创伤性脑损伤后不同干预方式下脑血流动力学的变化 ()
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《临床神经外科杂志》[ISSN:1672-7770/CN:32-1727/R]

卷:
16
期数:
2019年第1期
页码:
84-88
栏目:
临床研究
出版日期:
2019-02-18

文章信息/Info

Title:
Preliminary study on assessment of cerebral hemodynamics changes (under different intervention methods)after traumatic brain injury in rabbits by computed tomography perfusion imaging
作者:
陈克非代飞虎李光旭董吉荣王玉海郎巍巍
214044 无锡,中国人民解放军联勤保障部队第904医院神经外科(陈克非,代飞虎,李光旭,董吉荣,王玉海);放射科(郎巍巍)
Author(s):
CHEN Ke-fei DAI Fei-hu LI Guang-xu et al.
Department of Neurosurgery, the 101st Hospital of PLA, Clinical Medical School of Anhui Medical University, Wuxi 214044, China
关键词:
创伤性脑损伤CT灌注成像脑血流动力学
Keywords:
traumatic brain injury CT perfusion imaging cerebral hemodynamic
分类号:
R651.1+5;R445
DOI:
10.3969/j.issn.1672-7770.2019.01.020
文献标志码:
D
摘要:
目的探讨CT灌注成像评估兔创伤性脑损伤后不同干预方式下脑血流动力学的变化。方法将40只新西兰白兔随机分为对照组(10只)和脑损伤组(30只)。采用硬膜外球囊注水加压的方法制作脑损伤兔模型,脑损伤组兔根据不同的干预方式又分为加压组、常规减压组及控制减压组(每组各10只)。所有动物制模成功后即行常规CT及CT灌注成像检查。在CT灌注成像参数图上测量4组动物的相关血流动力学参数值——局部脑血流量(rCBF)、局部脑血容量(rCBV)及平均通过时间(MTT),并进行比较。检查结束后,从兔耳缘静脉注入2%伊文思蓝,处死并取脑组织;检测各组兔脑组织伊文思蓝的含量。结果脑损伤组基底节区及颞叶的rCBF、 rCBV均显著低于对照组,而MTT均明显长于对照组,差异有统计学意义(均P<0.01)。脑损伤不同干预方式组之间的rCBF、rCBV及MTT比较,差异也有统计学意义(均P<0.01)。脑损伤组兔脑组织的伊文思蓝含量高于对照组,差异有统计学意义(均P<0.01);脑损伤组组间比较,差异也有统计学意义(均P<0.01)。结论CT灌注成像能较好地评估创伤性脑损伤后脑血流动力学的变化。控制性减压的干预方式,可使创伤性脑损伤后脑血流动力学的异常变化得到一定程度的缓解。
Abstract:
Abstract:ObjectiveTo explore the cerebral hemodynamics changes of traumatic brain injury in rabbits under different interventions by computed tomography perfusion(CTP) imaging. MethodsForty New Zealand white rabbits were randomly divided into control,compression, common decompression and controlled decompression group. The animal model was established by injecting water into a balloon in the epidural space of rabbit under intracranial pressure monitoring. The common decompression and controlled decompression groups, in addition to interventions, received two different procedures of decompression. Conventional CT scan and CTP imaging were performed after the animal model successfully constructed. The regional cerebral blood flow(rCBF), the regional cerebral blood volume(rCBV) and mean transit time(MTT) of interest of each group were determined and compared statistically. The blood brain barrier(BBB) permeability was evaluated by Evans blue assay. ResultsBoth the values of rCBF and rCBV in the basal ganglia region and temporal lobe were prominently lower in compression, common decompression and controlled decompression group than those in control group, while the values of MTT were significantly longer(All P<0.01). There were also significant differents in the values of rCBF, rCBF and MTT in the groups(All P<0.01). The content of Evans blue in the experimental group was higher than that in the control group(All P<0.01), and the difference was also statistically significant among the groups(All P<0.01). ConclusionsCTP imaging palys a key role in evaluating the changes of cerebral hemodynamics after traumatic brain injury. Controlled decompression can relieve the abnormal changes of cerebral hemodynamics after brain injury.

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更新日期/Last Update: 2019-02-18