[1]赵英玉,梅鹏金,苗发安,等.内镜经鼻蝶入路手术治疗不同Knosp分级垂体瘤的疗效分析[J].临床神经外科杂志,2019,16(2):129-133.[doi:10.3969/j.issn.1672-7770.2019.02.008]
 ZHAO Ying-yu,MEI Peng-jin,MIAO Fa-an,et al.Efficacy of extended endoscopic endonasal transsphenoidal approach for removal of different Knosp grades pituitary tumors[J].Journal of Clinical Neurosurgery,2019,16(2):129-133.[doi:10.3969/j.issn.1672-7770.2019.02.008]
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内镜经鼻蝶入路手术治疗不同Knosp分级垂体瘤的疗效分析()
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《临床神经外科杂志》[ISSN:1672-7770/CN:32-1727/R]

卷:
16
期数:
2019年第2期
页码:
129-133
栏目:
垂体瘤专题
出版日期:
2019-04-17

文章信息/Info

Title:
Efficacy of extended endoscopic endonasal transsphenoidal approach for removal of different Knosp grades pituitary tumors
作者:
赵英玉梅鹏金苗发安蒋昊马贺范月超
221000 徐州,徐州医科大学附属医院神经外科
Author(s):
ZHAO Ying-yu MEI Peng-jin MIAO Fa-an et al.
Department of Neurosurgery,the Affiliated Hospital of Xuzhou Medical University, Xuzhou 221000, China
关键词:
神经内镜垂体瘤临床疗效并发症
Keywords:
neuroendoscopepituitary tumorstreatment outcomecomplication
分类号:
R739.41
DOI:
10.3969/j.issn.1672-7770.2019.02.008
文献标志码:
A
摘要:
【摘要】目的 探讨内镜经鼻蝶扩大入路手术治疗不同Knosp分级垂体瘤的临床疗效。方法回顾性分析徐州医科大学附属医院神经外科自2016年9月—2018年2月,应用内镜经鼻蝶扩大入路手术治疗92例不同Knosp分级垂体瘤患者的临床资料;比较不同Knosp分级患者的垂体瘤切除程度及并发症发生率及功能型垂体瘤患者激素水平缓解情况。结果本组患者中全切者69例,近全切患者17例,次全切患者5例,部分切除患者1例;Knosp分级0~2级垂体瘤患者的全切率(90.5%)明显高于Knosp分级3~4级患者(41.4%),差异具有统计学意义(P<0.05)。Knosp分级0~2级患者的手术并发症发生率明显低于3~4级患者;Knosp分级0~2级和3~4级功能型垂体瘤患者的术后激素水平总的治愈率无明显差异。结论内镜经鼻蝶扩大入路治疗不同Knosp分级垂体瘤是一种安全、有效的手术方法,尤其是对于Knosp分级0~2级的患者。
Abstract:
Abstract: ObjectiveTo explore the efficacy of extended endoscopic endonasal transsphenoidal approach(EEETA) for removal of different Knosp grades pituitary tumors. MethodsThe clinical data of 92 patients admitted to the Affiliated Hospital of Xuzhou Medical University from September 2016 to March 2018 that underwent removal of pituitary tumors in different Knosp grades via endoscopic endonasal transsphenoidal approach were analyzed retrospectively. The resection rate,clinical cured rate and complications in different Knosp grades pituitary tumors were compared and analyzed. ResultsGross total resection(GTR) were achieved in 69 patients, and near-total resection in 17, sub-total resection in 5 and partial resection in 1. The rate of GTR in different Knosp classifications were significantly different, the rate of gross total resection in Knosp grades 0-2 patients(90.5%) was statistically higher than Knosp grades 3-4 (41.4%)(P<0.05). The rate of complications in Knosp grade 0-2 patients was statistically lower than that of grade 3-4 patients,and there was no significant difference in the total cure rate of postoperative hormone levels in patients with Knosp grade 0-2 and grade 3-4 functional pituitary tumors. ConclusionEndoscopic endonasal transsphenoidal approach is a safe and effective method for resection of suprasellar pituitary tumors,especially for patients with grade 0-2.

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更新日期/Last Update: 2019-04-17