[1]郑重,王秀,桑林,等.胚胎发育不良性神经上皮肿瘤继发癫痫的手术疗效及预后影响因素分析[J].临床神经外科杂志,2019,16(4):314-318.[doi:10.3969/j.issn.1672-7770.2019.04.008]
 ZHENG Zhong,WANG Xiu,SANG Lin,et al.Surgical treatment of epilepsy due to dysembryoplastic neuroepithelial tumor and prognosis of seizure outcome[J].Journal of Clinical Neurosurgery,2019,16(4):314-318.[doi:10.3969/j.issn.1672-7770.2019.04.008]
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胚胎发育不良性神经上皮肿瘤继发癫痫的手术疗效及预后影响因素分析()
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《临床神经外科杂志》[ISSN:1672-7770/CN:32-1727/R]

卷:
16
期数:
2019年第4期
页码:
314-318
栏目:
癫痫专题
出版日期:
2019-08-15

文章信息/Info

Title:
Surgical treatment of epilepsy due to dysembryoplastic neuroepithelial tumor and prognosis of seizure outcome
作者:
郑重王秀桑林李冬智杨晓丽马延山张建国张凯李敬军
100070 北京,北京丰台医院神经外科(郑重,桑林,李冬智,杨晓丽,马延山);首都医科大学附属北京天坛医院神经外科(王秀,张建国,张凯);北京市神经外科研究所(李敬军)
Author(s):
ZHENG Zhong WANG Xiu SANG Lin et al.
Department of Neurosurgery, Beijing Fengtai Hospital, Beijing 100070, China
关键词:
胚胎发育不良性神经上皮肿瘤癫痫手术治疗预后因素
Keywords:
dysembryoplastic neuroepithelial tumor epilepsy surgical treatment prognostic factors
分类号:
R742.1
DOI:
10.3969/j.issn.1672-7770.2019.04.008
文献标志码:
A
摘要:
【摘要】目的 探讨外科手术治疗胚胎发育不良性神经上皮肿瘤(DNT)继发癫痫的临床疗效及影响预后的相关因素。方法回顾性分析北京丰台医院癫痫中心2009年11月—2017年11月收治的37例病理证实为DNT的癫痫患者的临床资料。根据Engel分级评估患者的预后;并分析患者的性别、发病年龄、病程、癫痫发作类型、病变部位、影像学特点、切除方式等因素与预后的关系。结果本组患者术后平均随访(55.4±28.0)个月,其中33例患者(89.2%)术后癫痫发作完全消失(Engel Ⅰ级)。分析结果显示,病程越短、病灶切除完全的患者预后越好(均P<0.05)。结论DNT所致癫痫的手术治疗效果较好,早期、完全切除病变是影响手术预后的重要因素。
Abstract:
Abstract: ObjectiveTo explore the clinical prognosis of surgical treatment of epilepsy secondary to dysembryoplastic neuroepithelial tumor(DNT) and the related factors affecting the prognosis of epilepsy. MethodsThe clinical data of 37 epilepsy patients with histologically proved by DNT who were admitted to Epilepsy Center, Beijing Fengtai Hospital from November 2009 to November 2017 were analyzed retrospectively. The relationship between prognosis and gender, age of onset, course of disease, type of epilepsy, location of lesion, imaging features, resection methods and other factors was analyzed. The patients were divided into favorable group(EngelⅠ) and unfavorable group(EngelⅡ-Ⅳ) according to postoperative seizure outcome. Statistical methods were analyzed by chi-square test and independent sample t-test. Results37 patients were followed up for an average of(55.4+28.0) months, and 33 patients(89.2%) had complete disappearance of epileptic seizures(Engel Ⅰ). The analysis showed that short epilepsy duration and completeness of resection would have a favorable seizure outcome(P<0.05). ConclusionsSurgical treatment of epilepsy caused by DNT is effective. Early surgery and completeness of resection are significantly associated with post-operative seizure outcome in epilepsy patients with DNT.

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更新日期/Last Update: 2019-08-01