[1]刘志远,刘晓阳,章佳跃,等.儿童鞍区恶性混合性生殖细胞肿瘤1例报告并文献复习[J].临床神经外科杂志,2019,16(5):447-450.[doi:10.3969/j.issn.1672-7770.2019.05.017]
 LIU Zhi-yuan,LIU Xiao-yang,ZHANG Jia-yue,et al.Intracranial germ cell tumors(report of one case and review of literature)[J].Journal of Clinical Neurosurgery,2019,16(5):447-450.[doi:10.3969/j.issn.1672-7770.2019.05.017]
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儿童鞍区恶性混合性生殖细胞肿瘤1例报告并文献复习 ()
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《临床神经外科杂志》[ISSN:1672-7770/CN:32-1727/R]

卷:
16
期数:
2019年第5期
页码:
447-450
栏目:
临床研究
出版日期:
2019-10-15

文章信息/Info

Title:
Intracranial germ cell tumors(report of one case and review of literature)
作者:
刘志远刘晓阳章佳跃赵鹏鲁艾林
210029 南京,南京医科大学第一附属医院神经外科
Author(s):
LIU Zhi-yuan LIU Xiao-yang ZHANG Jia-yue et al.
Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
关键词:
颅内生殖细胞肿瘤绒毛膜促性腺激素甲胎蛋白诊断性放化疗
Keywords:
intracranial germ cell tumor chorionic gonadotropin alphafetoprotein diagnostic chemoradiotherapy
分类号:
R739.41
DOI:
10.3969/j.issn.1672-7770.2019.05.017
文献标志码:
D
摘要:
【摘要】目的 探讨颅内生殖细胞瘤(intracranial germ cell tumors,ICGCTs)的临床表现、诊断方法和治疗方案。方法回顾性分析南京医科大学第一附属医院收治的1例鞍区混合性生殖细胞肿瘤患者的临床资料,并复习相关文献。结果本例患者临床表现为多饮、多尿、视物模糊、视野变窄;垂体MRI检查示鞍区及鞍上区见类圆形混杂信号影;行颅底肿瘤切除术;术后病理检查证实为恶性混合性生殖细胞肿瘤(绒毛膜癌+生殖细胞瘤)。患者术后1个月开始辅助放疗,现已放疗结束,累积放疗剂量DT 40 Gy/20 f。随访3个月,患者症状明显好转。结论ICGCTs症状随部位不同而有所不同,瘤标、诊断性放化疗在其诊断中具有重要作用,治疗方案视组织类型而定,单纯生殖细胞瘤的预后较好。
Abstract:
Abstract: ObjectiveTo summarize the clinical manifestations,diagnostic methods and therapeutic regimen of intracranial germ cell tumors(ICGCTs). MethodsThe clinical date of a child patient with mixed germ cell tumor in the sellar region was analyzed retrospectively and relevant literature was reviewed. ResultsThe patient showed central diabetes insipidus, blurred vision, narrow field of vision. Pituitary MR showed circular mixed signals, postoperative pathological examination confirmed it as a malignant mixed germ cell tumor(choriocarcinoma and germinoma). Auxiliary radiotherapy was performed after a month of surgery with a cumulative radiation dose of DT 40 gy / 20 f. The follow-up of 3 months showed the patients symptoms improved significantly. ConclusionsThe symptoms of ICGCTs vary for different location of tumors. Tumor markers and diagnostic radiochemotherapy play an important role in its diagnosis. Therapeutic regimen depends on the type of tissues.
更新日期/Last Update: 2019-10-15