[1]梁博,梁庭毓,王芳,等.microRNA-424表达与脑胶质瘤级别、预后、化疗敏感性的关系及其机制[J].临床神经外科杂志,2019,16(6):461-464471.[doi:10.3969/j.issn.1672-7770.2019.06.001]
 LIANG Bo,LIANG Ting-yu,WANG Fang,et al.Relationship between the expression of microRNA-424 and the glioma grades, prognosis and chemosensitivity and its mechanism[J].Journal of Clinical Neurosurgery,2019,16(6):461-464471.[doi:10.3969/j.issn.1672-7770.2019.06.001]
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microRNA-424表达与脑胶质瘤级别、预后、化疗敏感性的关系及其机制()
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《临床神经外科杂志》[ISSN:1672-7770/CN:32-1727/R]

卷:
16
期数:
2019年第6期
页码:
461-464471
栏目:
胶质瘤研究
出版日期:
2019-12-10

文章信息/Info

Title:
Relationship between the expression of microRNA-424 and the glioma grades, prognosis and chemosensitivity and its mechanism
作者:
梁博梁庭毓王芳王小永冯恩山
100015 北京,首都医科大学附属北京地坛医院神经外科
Author(s):
LIANG Bo LIANG Ting-yu WANG Fang et al.
Department of Neurosurgery, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
关键词:
脑胶质瘤microRNA-424预后化疗
Keywords:
cerebral glioma microRNA-424 prognosis chemotherapy
分类号:
R739.41
DOI:
10.3969/j.issn.1672-7770.2019.06.001
文献标志码:
A
摘要:
【摘要】目的探讨microRNA-424表达与脑胶质瘤级别、预后、化疗敏感性及IDH1表型、Ki67蛋白表达的关系。方法从中国脑胶质瘤谱图计划(CGGA)中选取198例有临床随访信息的脑胶质瘤患者。比较不同分组患者的microRNA-424表达量,microRNA-424不同表达量患者的生存期及无进展生存期、化疗效果;Ki67蛋白表达量和IDH1表型与microRNA-424表达的关系。结果microRNA-424表达量与肿瘤级别呈正比。IDH1野生型及Ki67蛋白高表达患者的microRNA-424表达量均升高(均P<0.05)。microRNA-424高表达患者的预后明显比低表达患者差,且脑胶质瘤更容易复发。microRNA-424低表达患者对化疗较敏感,放疗+化疗患者的生存期明显比单纯放疗患者长(P=0.007)。结论microRNA-424可以作为脑胶质瘤诊断和预测治疗效果及预后的生物标志物。
Abstract:
Abstract: ObjectiveTo investigate the relationship between microRNA-424 expression and glioma grades, prognosis, chemosensitivity, IDH1 phenotype and Ki67 expression. Methods198 followed-up glioma patients were selected from the Chinese Glioma Genome Atlas (CGGA). The expression of microRNA-424 in different groups of patients, and the survival time, progression-free survival time and chemotherapeutic effect of patients with different expression levels of microRNA-424 were compared. The relationship between expression of Ki67 protein and IDH1 phenotype and microRNA-424 expression was analyzed. ResultsThe expression of microRNA-424 was positively correlated with tumor grades. The expression of microRNA-424 increased in IDH1 wild type and Ki67 protein overexpression patients (all P<0.05). The prognosis of patients with high expression of microRNA-424 was significantly worse than that of patients with low expression of microRNA-424, and glioma recurred more easily. The patients with low expression of microRNA-424 were more sensitive to chemotherapy. The survival time of patients with radiotherapy plus chemotherapy was significantly longer than that of patients with radiotherapy alone(P=0.007). Conclusion MicroRNA-424 can be used as a biomarker for the diagnosis, treatment and prognosis of glioma.

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更新日期/Last Update: 2019-12-10