[1]夏小雨,白洋,杨艺,等.颅脑外伤后微意识状态重复经颅磁刺激促醒治疗的研究[J].临床神经外科杂志,2020,17(01):11-15.[doi:DOI:10.3969/j.issn.1672-7770.2020.01.004]
 TBI XIA Xiao-yu,BAI Yang,YANG Yi,et al.Study on repetitive transcranial magnetic stimulation in MCS patients after[J].Journal of Clinical Neurosurgery,2020,17(01):11-15.[doi:DOI:10.3969/j.issn.1672-7770.2020.01.004]
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颅脑外伤后微意识状态重复经颅磁刺激促醒治疗的研究()
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《临床神经外科杂志》[ISSN:1672-7770/CN:32-1727/R]

卷:
17
期数:
2020年01期
页码:
11-15
栏目:
意识障碍专题
出版日期:
2020-02-15

文章信息/Info

Title:
Study on repetitive transcranial magnetic stimulation in MCS patients after
文章编号:
202001004
作者:
夏小雨白洋杨艺党圆圆王东东黄瑞景富延斌何江弘
100700 北京,中国人民解放军总医院第七医学中心神经外科(夏小雨,杨艺,党圆圆,黄瑞景,富延斌,何江弘);杭州师范大学国际植物状态与意识科学研究所(白洋);三河市燕郊人民医院(王东东)
Author(s):
TBI XIA Xiao-yu BAI Yang YANG Yi et al.
Department of Neurosurgery, the Seventh Medical Center of PLA General Hospital, Beijing 100700, China
关键词:
意识障碍颅脑外伤微意识状态经颅磁刺激
Keywords:
disorders of consciousness traumatic brain injury minimally consciousness state transcranial magnetic stimulation
分类号:
R651.1+5
DOI:
DOI:10.3969/j.issn.1672-7770.2020.01.004
文献标志码:
A
摘要:
目的探讨左侧额叶背外侧区的高频重复经颅磁刺激治疗颅脑外伤后微意识状态的效果和安全性。方法将中国人民解放军总医院第七医学中心神经外科2015年12月—2016年9月收治的颅脑外伤后微意识状态患者32例,分为经颅磁刺激治疗组(磁刺激组)和对照组;磁刺激组患者接受经颅磁刺激治疗,对照组患者在同样的时间段内接受假刺激。疗效评价指标为治疗前后昏迷恢复量表修订版(CRS-R)评分的变化(组间对比,基线与治疗终点对比)。结果磁刺激组患者意识改善率为64.7%,对照组意识改善率为13.3%。治疗终点与基线对比,磁刺激组CRS-R评分提升明显,对照组CRS-R评分无明显提升。所有患者在治疗全程中无不良事件发生。结论左侧额叶背外侧区重复经颅磁刺激治疗对颅脑外伤后微意识状态患者有较为明确的促醒调控作用,并且该治疗安全。
Abstract:
Objective To evaluate the efficacy and safety of high-frequency repetitive transcranial magnetic stimulation(rTMS) over left dorsolateral prefrontal cortex(DLPFC) for the treatment of minimally consciousness state(MCS) due to traumatic brain injury(TBI). Methods From December 2015 to September 2016, 32 MCS patients due to TBI were admitted to the department of neurosurgery, the Seventh Medical Center of PLA General Hospital. They were divided into transcranial magnetic stimulation treatment group and control group. The treatment group received transcranial magnetic stimulation. The control group received sham stimulation during the same period of time. The evaluation index was the change in the score of the revised coma recovery scale(CRS-R) (comparison between groups, baseline vs. treatment endpoint). ResultsThe improvement rate of consciousness in the treatment group was 64.7%, compared with 13.3% in the control group. Compared the baseline, a significant increase of CRS-R score in the treatment group was found than no significant improvement in the control group. No adverse events occurred in all cases during the treatment. ConclusionThe 10 Hz high-frequency repetitive transcranial magnetic stimulation over left dorsolateral prefrontal cortex has a definite awakening regulation effect on MCS patients due to TBI, and stimulation with this parameter is safe.

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更新日期/Last Update: 2020-02-18