[1]史有才,邹世浩,王坤,等.丘脑底核脑深部电刺激术后恶性帕金森病综合征(附2例报告)[J].临床神经外科杂志,2020,17(03):354-357.[doi:DOI:10.3969/j.issn.1672-7770.2020.03.025]
 SHI You-cai,ZOU Shi-hao,WANG Kun,et al.Parkinsonism malignant syndrome following deep brain stimulation surgery of subthalamic nucleus(report of 2 cases)[J].Journal of Clinical Neurosurgery,2020,17(03):354-357.[doi:DOI:10.3969/j.issn.1672-7770.2020.03.025]
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丘脑底核脑深部电刺激术后恶性帕金森病综合征(附2例报告)()
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《临床神经外科杂志》[ISSN:1672-7770/CN:32-1727/R]

卷:
17
期数:
2020年03期
页码:
354-357
栏目:
病例报告
出版日期:
2020-06-15

文章信息/Info

Title:
Parkinsonism malignant syndrome following deep brain stimulation surgery of subthalamic nucleus(report of 2 cases)
文章编号:
202003025
作者:
史有才邹世浩王坤藏健华修彬华郑刚姜伊昆杨江河
830000 乌鲁木齐,新疆军区总医院神经外科(史有才,邹世浩,修彬华,郑刚,姜伊昆,杨江河),特诊科(王坤),磁共振室(藏健华);新疆医科大学第二附属医院神经调控中心(史有才)
Author(s):
SHI You-cai ZOU Shi-hao WANG Kun et al.
Department of Neurosurgery, General Hospital of Xinjiang Military Command, Urumqi 830000, China
关键词:
帕金森病丘脑底核脑深部电刺激恶性帕金森病综合征高热
Keywords:
Parkinsons disease STN-DBS Parkinsonism malignant syndrome hyperpyrexia
分类号:
R742.5
DOI:
DOI:10.3969/j.issn.1672-7770.2020.03.025
文献标志码:
B
摘要:
目的探讨帕金森病(PD)患者丘脑底核脑深部电刺激(STN-DBS)术后发生恶性综合征(PMS)的临床特点及治疗措施。方法回顾分析2例PD患者在STN-DBS治疗过程中发生帕金森PMS的临床资料。结果患者的主要临床表现为意识障碍、肢体僵硬、运动不能、高热、自主神经功能紊乱等典型或非典型临床症状。经联合用药及增加抗PD药物剂量,调控提高DBS刺激参数等综合治疗后,患者的生命体征恢复正常,异动消失,病情稳定出院。结论在DBS术前后应注意适当减少抗PD药用量,并早期发现、早期处理PMS,能取得显著的效果。但患者的病情难与恢复到PMS之前的基线水平。
Abstract:
Objective To investigate the clinical characteristics and management of parkinsonism malignant syndrome(PMS) in patients with Parkinsons disease(PD) after deep brain stimulation of the subthalamic nucleus(STN-DBS). Methods The clinical data of 2 patients with PD during STN-DBS occurred to Parkinsonism malignant syndrome were analyzed retrospectively. Results Their clinical features consisted of sustained altered consciousness, rigidity of limbs, dyskinesias, high body temperature and autonomic instability. The vital signs returned to normal, the abnormal movement disappeared and the patients were discharged from hospital in a stable condition after comprehensive treatment including regulation and improvement of DBS stimulation parameters, which may accelerate the patients recovery. Conclusions In perioperative period of DBS should be appropriate to decrease anti-parkinsons drugs. Early recognition and treatment are keys to the successful management, including reducing anti-parkinsons drugs properly. However, once this happen, it is difficult to get back to the baseline.

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更新日期/Last Update: 2020-06-17