[1]路营营,杜浩,黄玲玥,等.乳头状瘤型脑膜瘤1例报告并文献复习[J].临床神经外科杂志,2020,17(03):357-360.[doi:DOI:10.3969/j.issn.1672-7770.2020.03.026]
 LU Ying-ying,DU Hao,HUANG Ling-yue,et al.Papillary meningioma(report of one case and review of literature)[J].Journal of Clinical Neurosurgery,2020,17(03):357-360.[doi:DOI:10.3969/j.issn.1672-7770.2020.03.026]
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乳头状瘤型脑膜瘤1例报告并文献复习()
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《临床神经外科杂志》[ISSN:1672-7770/CN:32-1727/R]

卷:
17
期数:
2020年03期
页码:
357-360
栏目:
病例报告
出版日期:
2020-06-15

文章信息/Info

Title:
Papillary meningioma(report of one case and review of literature)
文章编号:
202003026
作者:
路营营杜浩黄玲玥何远志邓文月战伟萍
430016 武汉,华中科技大学同济医学院附属武汉儿童医院神经外科(路营营,杜浩,黄玲玥,何远志,邓文月);莱州市妇幼保健院儿科(战伟萍)
Author(s):
LU Ying-ying DU Hao HUANG Ling-yue et al.
Department of Pediatric Neurosurgery, Wuhan Childrens Hospital(Wuhan Maternal and Child Healthcare Hospital), Tongji
关键词:
乳头状瘤型脑膜瘤免疫组织化学病理学
Keywords:
papillary meningioma immunohistochemistry pathology
分类号:
R739.41
DOI:
DOI:10.3969/j.issn.1672-7770.2020.03.026
文献标志码:
B
摘要:
目的探讨乳头状瘤型脑膜瘤的临床、影像及病理学特征。方法对1例乳头状瘤型脑膜瘤患儿的临床表现、影像学及病理免疫组织化学染色结果进行分析;并对相关文献进行复习。结果本例患儿,男,1岁11个月;主诉间断意识丧失伴呕吐1周入院。头颅MRI增强扫描示,右侧顶枕部囊实性占位,基底池周围脑膜明显异常强化。行手术切除肿瘤。组织病理学检查可见:肿瘤分界不清,肿瘤细胞大小不等,细胞核圆形、椭圆形或长梭形,部分核内可见假包涵体,核分裂像多见,核仁不明显,胞浆红染,可见少量瘤巨细胞;部分瘤细胞密集排列,部分区域瘤细胞围绕血管,呈假菊形团。免疫组化染色:EMA(+),S-100(+),CD99(+),Ki-67(+)抗原标记指数为10%,PGP9.5(+),NF(-),GFAP(-),NeuN(-)。结论乳头状瘤型脑膜瘤临床少见,恶性程度高,预后不良影像学及肿瘤标志物有一定的特征性表现,诊断需要根据病理形态学特点确定。
Abstract:
Objective To investigate the clinical,image and pathological characteristics of papillary meningioma. Methods The clinical manifestations, imaging, histopathological and immunohistochemical results of a patient with papillary meningioma were analyzed retrospectively and the related literature were reviewed. ResultsThe patient was twenty-three months years old. The chief complaints were intermittent loss of consciousness and vomiting. Magnetic resonance imaging(MRI) examination revealed the right periventricular with cystic-solid signal, basal cistern meningeal with distinct enhancement. Histopathological examination showed there was not clear boundary between tumor and normal tissue. The tumor cells varied in size and shape. Nucleus showed circular, oval or spindle shape. Partial nucleus showed there was pseudo inclusion, common mitotic, inconspicuous nucleolus, cytoplasm red dye and few tumor giant cell. Some oncocytes arrary together, perivascular shape rosettes. Immunohistochemical analysis showed a positive reaction for epithelial membrane antigen (EMA), S-100 protein and CD99. The Ki-67 positive rate was 10%. NF, GFAP and NeuN expression was negtive in this case. Conclusions Papillary meningioma is a rare tumor, which has high malignancy and poor prognosis. There are particular image manifestations features. The diagnosis may depend on pathological immunohistochemical features.

相似文献/References:

[1]胡飞,邵强.颅内孤立性纤维瘤的诊断和治疗(2例报告并文献复习)[J].临床神经外科杂志,2015,(04):293.
[2]苗发安,陈晨,范月超.端粒结合蛋白-1在脑胶质瘤中的表达及临床意义[J].临床神经外科杂志,2014,(02):94.

更新日期/Last Update: 2020-06-17