[1]丁建波,王滨江,许云,等.脑膜瘤分阶段伽玛刀放射外科治疗的策略及疗效分析[J].临床神经外科杂志,2020,17(04):452-458.[doi:DOI:10.3969/j.issn.1672-7770.2020.04.021]
 DING Jian-bo,WANG Bin-jiang,XU Yun,et al.Innovative strategy of staged Gamma knife radiosurgery for meningiomas and the analysis for the results[J].Journal of Clinical Neurosurgery,2020,17(04):452-458.[doi:DOI:10.3969/j.issn.1672-7770.2020.04.021]
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脑膜瘤分阶段伽玛刀放射外科治疗的策略及疗效分析()
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《临床神经外科杂志》[ISSN:1672-7770/CN:32-1727/R]

卷:
17
期数:
2020年04期
页码:
452-458
栏目:
临床研究
出版日期:
2020-08-14

文章信息/Info

Title:
Innovative strategy of staged Gamma knife radiosurgery for meningiomas and the analysis for the results
文章编号:
202004021
作者:
丁建波王滨江许云潘力王恩敏张南于同刚陈晶晶董艳
200235 上海,上海伽玛医院神经外科(丁建波,王滨江,潘力,张南,陈晶晶),放射科(于同刚),护理部(董艳);南京医科大学附属脑科医院伽玛刀治疗中心(许云);复旦大学附属华山医院神经外科(王恩敏)
Author(s):
DING Jian-bo WANG Bin-jiang XU Yun et al.
Department of Neurosurgery, Shanghai Gamma Hospital, Shanghai 200235, China
关键词:
脑膜瘤伽玛刀放射外科分阶段放射外科
Keywords:
meningioma Gamma knife radiosurgery staged radiosurgery
分类号:
R739.41
DOI:
DOI:10.3969/j.issn.1672-7770.2020.04.021
文献标志码:
B
摘要:
目的探索存在手术禁忌证的体积较大或靠近重要神经结构的脑膜瘤患者的分阶段伽玛刀放射外科治疗的策略及其疗效。方法80例脑膜瘤患者,其中61例患者接受剂量分割分阶段放射外科治疗,单次周边剂量为7~11 Gy,40%~50%的等剂量线;19例患者接受体积分割分阶段放射外科治疗,单次周边剂量为8~14 Gy,40%~50%的等剂量线。分阶段治疗的时间间隔为3~17个月,平均(9.1±3.1)个月。治疗后随访时间为6~72个月,平均(36.5±7.2)个月。结果所有患者均顺利完成治疗计划,未出现严重不良反应和新发神经功能障碍者。两个阶段治疗后6个月、1年、2年和3年患者的肿瘤体积分别缩小了(25.27±19.13)%、(24.98±19.82)%、(30.49±17.64)%和(32.12±16.55)%。结论对于体积较大或邻近重要结构的脑膜瘤采用分阶段伽玛刀放射外科治疗有显著的效果和安全性;该治疗方案为存在开颅手术禁忌证的脑膜瘤患者提供了一个最佳的治疗选择。
Abstract:
To explore the strategy and curative effects of staged Gamma knife radiosurgery for patients with surgical contraindications suffering from large meningiomas or meningiomas close to important nerve structures. Methods 80 patients were included in the study. 61 patients were treated with dose-fractionated radiosurgery, with a single peripheral dose of 7-11 Gy, 40%-50% isodose line. 19 patients were treated with volume-fractionated radiosurgery, with a single peripheral dose of 8-14 Gy, 40%-50% isodose line. The treatment interval was 3-17(mean 9.1±3.1) months. The follow-up time was 6-72(mean 36.5±7.2) months. Results All patients successfully completed the treatment plan. No serious adverse reactions and new neurological dysfunction were found. Six months, one year, two years and three years after the two-stage treatment, the volume of tumor decreased by 25.27%±19.13%, 24.98%±19.82%, 30.49%±17.64% and 32.12%±16.55% respectively. Conclusion Staged Gamma knife radiosurgery provides significant effect and safety for meningiomas with large volume or adjacent to important structures, this treatment scheme provides an optimal treatment option for meningiomas with contraindications of craniotomy.

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更新日期/Last Update: 2020-08-18